Anil Makam, MD

Assoc Prof In Residence
Medicine

Anil Makam, MD, MAS, is a hospital medicine physician and a health services and policy researcher. His research is at the intersection of hospital medicine, geriatrics, and post-acute care, specifically focusing on the role of long-term acute care hospitals (LTACHs). His research interest stemmed from his observation that Dallas had many LTACHs whereas San Francisco had very few, yet he cared for similarly sick and frail hospitalized older adults in both places. His research has been funded by the NIA and the Donaghue Foundation. Dr. Makam applies health services research and epidemiological methods using Medicare claims, EHR data, and prospective observational cohort data to examine predictors and variation in LTACH use, comparative effectiveness of the LTACH model of care, and patterns and prognosis of recovery for older adults transferred to LTACHs, including a national multicenter COVID19 recovery cohort called RAFT COVID.

Dr. Makam also studies outcomes, utilization, and prognostication for other common conditions experienced by hospitalized adults including pneumonia, sepsis, acute coronary syndrome, end stage kidney disease, and diabetes; as well as the quality and the complications of inpatient medicine, such as hospital-acquired anemia, readmissions, vital signs, and core populations of safety net hospitals, including uninsured individuals, addiction medicine, jail health, and undocumented immigrants.

Dr. Makam is also deeply passionate about mentorship, evidence-based medicine and critical appraisal of the clinical scientific literature. He has published his framework for the practice of EBM as a State-of-the-Art review article in Circulation. He has also published a number of studies on EBM, high value care, and overuse of common medical practices. He has had extensive experience teaching EBM and critical appraisal to trainees and faculty members. At UCSF he is the Co-Director of the CTSI K-Grant Writing Workshop, an Inquiry Advisor for the School of Medicine, and Co-Director of Academic Development & Research for the Division of Hospital Medicine at San Francisco General Hospital. Nationally he peer reviews for leading medical journals and MedPAC reports to Congress, was an Associate Editor for the Journal of Hospital Medicine (2015-2023), and is an Evidence Author consultant for the Institute of Clinical and Economic Review, a leading voice in assessing the value of medical innovations. Lastly, he has an active presence on Twitter.

Dr. Makam’s research has been published in leading medical journals, including JAMA, JAMA Internal Medicine, Circulation, Journal of the American Geriatrics Society, BMJ Quality & Safety has been cited by the Institute of Medicine and Wikipedia articles; and has been featured in prominent news outlets, including the New York Times. He has received several research awards, including the Arti Hurria Memorial Award for Emerging Investigators in Internal Medicine Who are Focused on the Care of Older Adults by the American Geriatrics Society.

Publications: 

Acute Medical Care by Nocturnists: A Narrative Review.

Journal of general internal medicine

Haber LA, Tien J, Echaniz M, Makam AN

Unlinking time zero from test-negative controls exaggerates risk from COVID-19.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Makam AN

Iptacopan and danicopan for paroxysmal nocturnal hemoglobinuria.

Journal of managed care & specialty pharmacy

Fahim SM, Makam AN, Suh K, Carlson JJ, Richardson M, Herce-Hagiwara B, Dickerson R, Pearson SD, Agboola F

Survival, Function, and Cognition After Hospitalization in Long-Term Acute Care Hospitals.

JAMA network open

Jain S, Gan S, Nguyen OK, Sudore RL, Steinman MA, Covinsky K, Makam AN

One-Year Recovery Among Survivors of Prolonged Severe COVID-19: A National Multicenter Cohort.

Critical care medicine

Makam AN, Burnfield J, Prettyman E, Nguyen OK, Wu N, Espejo E, Blat C, Boscardin WJ, Ely EW, Jackson JC, Covinsky KE, Votto J, Recovery After Transfer to an LTACH for COVID-19 (RAFT COVID) Study

Staying against medical advice.

Journal of hospital medicine

Haber LA, Erickson HP, Makam AN

Characterizing patients hospitalized without an acute care indication: A retrospective cohort study.

Journal of hospital medicine

Rosenthal MA, Ranji SR, Kanzaria HK, Ortiz GM, Chase J, Chodos AH, Nguyen OK, Rodriguez EG, Makam AN

Prevalence and Characteristics of Hospitalizations with Unhealthy Alcohol Use in a Safety-Net Hospital from 2016 to 2018.

Journal of general internal medicine

Martin M, Clement J, Defries T, Makam AN, Nguyen OK

Are disruptions to geographic cohorting safe?

Journal of hospital medicine

Kohn R, Makam AN

Establishing Medicaid incentives for liberating nursing home patients from ventilators.

Journal of the American Geriatrics Society

Keohane LM, Mart MF, Ely EW, Lai P, Cheng A, Makam AN, Stevenson DG

National Prevalence of Alcohol and Other Substance Use Disorders Among Emergency Department Visits and Hospitalizations: NHAMCS 2014-2018.

Journal of general internal medicine

Suen LW, Makam AN, Snyder HR, Repplinger D, Kushel MB, Martin M, Nguyen OK

Availability of Palliative Care in Long-Term Acute Care Hospitals.

Journal of the American Medical Directors Association

Sumarsono N, Sudore RL, Smith AK, Pantilat SZ, Anderson WG, Makam AN

Policy in Clinical Practice: Choosing Post-Acute Care in the New Decade.

Journal of hospital medicine

Makam AN, Grabowski DC

Appropriateness of Long-Term Acute Care Hospital Transfer: A Multicenter Study of Medicare ACO Beneficiaries.

Journal of the American Medical Directors Association

Schumacher RC, Chiu M, de Leon J, Krause K, Makam AN

Man vs. Machine: Comparing Physician vs. Electronic Health Record-Based Model Predictions for 30-Day Hospital Readmissions.

Journal of general internal medicine

Nguyen OK, Washington C, Clark CR, Miller ME, Patel VA, Halm EA, Makam AN

Caring for Hospitalized Incarcerated Patients: Physician and Nurse Experience.

Journal of general internal medicine

Brooks KC, Makam AN, Haber LA

Factors Associated with Duration of Rehabilitation Among Older Adults with Prolonged Hospitalization.

Journal of the American Geriatrics Society

Nguyen DQ, Ifejika NL, Reistetter TA, Makam AN

Comparative effectiveness of long-term acute care hospital versus skilled nursing facility transfer.

BMC health services research

Makam AN, Nguyen OK, Miller ME, Shah SJ, Kapinos KA, Halm EA

Inclusion of Performance Parameters and Patient Context in the Clinical Practice Guidelines for Heart Failure.

Journal of cardiac failure

Goyal P, Unlu O, Kennel PJ, Schumacher RC, Gilstrap LG, Krishnaswami A, Allen LA, Maurer MS, Rich MW, Makam A

Can we predict early 7-day readmissions using a standard 30-day hospital readmission risk prediction model?

BMC medical informatics and decision making

Saleh SN, Makam AN, Halm EA, Nguyen OK

The Clinical Course after Long-Term Acute Care Hospital Admission among Older Medicare Beneficiaries.

Journal of the American Geriatrics Society

Makam AN, Tran T, Miller ME, Xuan L, Nguyen OK, Halm EA

Evidence-Based Medicine and the American Thoracic Society Guidelines-Reply.

JAMA internal medicine

Schumacher RC, Nguyen OK, Makam AN

Improving Respiratory Rate Accuracy in the Hospital: A Quality Improvement Initiative.

Journal of hospital medicine

Keshvani N, Berger K, Gupta A, DePaola S, Nguyen OK, Makam AN

Utility of Blood Cultures in Pneumonia.

The American journal of medicine

Zhang D, Yang D, Makam AN

Evidence-Based Medicine and the American Thoracic Society Clinical Practice Guidelines.

JAMA internal medicine

Schumacher RC, Nguyen OK, Deshpande K, Makam AN

Association of Scheduled vs Emergency-Only Dialysis With Health Outcomes and Costs in Undocumented Immigrants With End-stage Renal Disease.

JAMA internal medicine

Nguyen OK, Vazquez MA, Charles L, Berger JR, Quiñones H, Fuquay R, Sanders JM, Kapinos KA, Halm EA, Makam AN

Effect of Site-Neutral Payment Policy on Long-Term Acute Care Hospital Use.

Journal of the American Geriatrics Society

Makam AN, Nguyen OK, Kirby B, Miller ME, Xuan L, Halm EA

Long-Term Acute Care Hospital Use of Non-Mechanically Ventilated Hospitalized Older Adults.

Journal of the American Geriatrics Society

Makam AN, Nguyen OK, Xuan L, Miller ME, Halm EA

The Influence of Financial Strain on Health Decision-Making.

Journal of general internal medicine

Nguyen OK, Higashi RT, Makam AN, Mijares JC, Lee SC

Acute Myocardial Infarction Readmission Risk Prediction Models: A Systematic Review of Model Performance.

Circulation. Cardiovascular quality and outcomes

Smith LN, Makam AN, Darden D, Mayo H, Das SR, Halm EA, Nguyen OK

A Depressing Diagnostic Error.

The American journal of medicine

Chaulk AL, Wang JI, Makam AN

What Are the Opportunity Costs of Self-Financing Medical Education?

Academic medicine : journal of the Association of American Medical Colleges

Nguyen OK, Makam AN

Roadmap for improving the accuracy of respiratory rate measurements.

BMJ quality & safety

Keshvani N, Berger K, Nguyen OK, Makam AN

Incidence, Predictors, and Outcomes of Hospital-Acquired Anemia.

Journal of hospital medicine

Makam AN, Nguyen OK, Clark C, Halm EA

Predicting 30-Day Pneumonia Readmissions Using Electronic Health Record Data.

Journal of hospital medicine

Makam AN, Nguyen OK, Clark C, Zhang S, Xie B, Weinreich M, Mortensen EM, Halm EA

Predicting the Risk of Readmission in Pneumonia. A Systematic Review of Model Performance.

Annals of the American Thoracic Society

Weinreich M, Nguyen OK, Wang D, Mayo H, Mortensen EM, Halm EA, Makam AN

Vital Signs Are Still Vital: Instability on Discharge and the Risk of Post-Discharge Adverse Outcomes.

Journal of general internal medicine

Nguyen OK, Makam AN, Clark C, Zhang S, Xie B, Velasco F, Amarasingham R, Halm EA

Further Limitations of the HOSPITAL Score in US Hospitals.

JAMA internal medicine

Nguyen OK, Halm EA, Makam AN

Predicting all-cause readmissions using electronic health record data from the entire hospitalization: Model development and comparison.

Journal of hospital medicine

Nguyen OK, Makam AN, Clark C, Zhang S, Xie B, Velasco F, Amarasingham R, Halm EA

Relationship between hospital financial performance and publicly reported outcomes.

Journal of hospital medicine

Nguyen OK, Halm EA, Makam AN

Trends in Long-Term Acute Care Hospital Use in Texas from 2002-2011.

Annals of gerontology and geriatric research

Makam AN, Nguyen OK, Zhou J, Ottenbacher KJ, Halm EA

The Diagnostic Cascade of Incidental Findings: A Teachable Moment.

JAMA internal medicine

Nguyen LT, Sullivan CT, Makam AN

Response to Einhorn and colleagues.

Journal of the American Geriatrics Society

Makam AN, Steinman MA

Use of cardiac biomarker testing in the emergency department.

JAMA internal medicine

Makam AN, Nguyen OK

Envisioning a social-health information exchange as a platform to support a patient-centered medical neighborhood: a feasibility study.

Journal of general internal medicine

Nguyen OK, Chan CV, Makam A, Stieglitz H, Amarasingham R

Risk of thiazide-induced metabolic adverse events in older adults.

Journal of the American Geriatrics Society

Makam AN, Boscardin WJ, Miao Y, Steinman MA

Factors associated with primary vein graft occlusion in a multicenter trial with mandated ultrasound surveillance.

Journal of vascular surgery

Oresanya L, Makam AN, Belkin M, Moneta GL, Conte MS

The good, the bad and the early adopters: providers' attitudes about a common, commercial EHR.

Journal of evaluation in clinical practice

Makam AN, Lanham HJ, Batchelor K, Moran B, Howell-Stampley T, Kirk L, Cherukuri M, Samal L, Santini N, Leykum LK, Halm EA

Use and satisfaction with key functions of a common commercial electronic health record: a survey of primary care providers.

BMC medical informatics and decision making

Makam AN, Lanham HJ, Batchelor K, Samal L, Moran B, Howell-Stampley T, Kirk L, Cherukuri M, Santini N, Leykum LK, Halm EA

Identifying patients with diabetes and the earliest date of diagnosis in real time: an electronic health record case-finding algorithm.

BMC medical informatics and decision making

Makam AN, Nguyen OK, Moore B, Ma Y, Amarasingham R